sfrp1a

ID

ZDB-GENE-040310-5

Name

secreted frizzled-related protein 1a

Symbol

sfrp1a Nomenclature History

Previous Names

sfrp1
wu:fd19b09

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable Wnt-protein binding activity. Acts upstream of or within camera-type eye morphogenesis and positive regulation of signal transduction. Predicted to be active in extracellular region. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Orthologous to human SFRP1 (secreted frizzled related protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sfrp1a Human Ortholog

No data available

Associated With sfrp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001134	Netrin domain
Domain	IPR018933	Netrin module, non-TIMP type
Domain	IPR020067	Frizzled domain
Family	IPR015526	Frizzled/secreted frizzled-related protein
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q7T2K9	InterPro	296
UniProtKB:A0AC58JI57	InterPro	296
UniProtKB:A0AC58JI61	InterPro	296
UniProtKB:A0AC58JI63	InterPro	296
UniProtKB:A0AC58JI71	InterPro	296
UniProtKB:A0AC58JI77	InterPro	296