ZFIN Morpholino: MO1-s1pr2

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-s1pr2

No data available

Phenotype

Phenotype resulting from MO1-s1pr2

Phenotype	Fish	Figures
anterior lateral line neuromast hair cell decreased amount, abnormal	WT + MO1-s1pr2	Fig. 3 from Hu et al., 2013
anterior lateral line neuromast hair cell development disrupted, abnormal	WT + MO1-s1pr2	Fig. 3 from Hu et al., 2013
cardiac muscle progenitor cell migration to the midline involved in heart field formation decreased occurrence, abnormal	ha01Tg + MO1-s1pr2	Fig. 1 , Fig. 2 , Fig. 3 from Fukui et al., 2014
cardioblast migration to the midline involved in heart rudiment formation decreased process quality, abnormal	ko07Tg + MO1-s1pr2	Fig. S1 from Hisano et al., 2013
cardioblast migration to the midline involved in heart rudiment formation disrupted, abnormal	ko07Tg + MO1-s1pr2	Fig. S1 from Hisano et al., 2013

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Phenotype of all Fish created by or utilizing MO1-s1pr2

Phenotype	Fish	Conditions	Figures
pharyngeal endoderm mislocalised laterally, abnormal	AB + MO1-s1pr2	standard conditions	Fig. 2 from Fukui et al., 2014
cardiac muscle progenitor cell migration to the midline involved in heart field formation decreased occurrence, abnormal	AB + MO1-s1pr2	standard conditions	Fig. 1 from Fukui et al., 2014
myocardial precursor mislocalised laterally, abnormal	AB + MO1-s1pr2	standard conditions	Fig. 1 from Fukui et al., 2014
heart tube split bilaterally, abnormal	AB + MO1-s1pr2	standard conditions	Fig. 1 from Fukui et al., 2014
embryonic heart tube morphogenesis disrupted, abnormal	AB/TU + MO1-s1pr2	standard conditions	Fig. 3 from Nakanaga et al., 2014

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Citations

Include unpublished citations

Kidokoro, H., Saijoh, Y., Schoenwolf, G.C. (2022) Nodal signaling regulates asymmetric cellular behaviors, driving clockwise rotation of the heart tube in zebrafish. Communications biology. 5:996
Wu, R.S., Lam, I.I., Clay, H., Duong, D.N., Deo, R.C., Coughlin, S.R. (2018) A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish. Developmental Cell. 46:112-125.e4
Bodrikov, V., Welte, C., Wiechers, M., Weschenfelder, M., Kaur, G., Shypitsyna, A., Pinzon-Olejua, A., Bastmeyer, M., Stuermer, C.A.O. (2017) Substrate properties of zebrafish Rtn4b/Nogo and axon regeneration in the zebrafish optic nerve. The Journal of comparative neurology. 525(14):2991-3009
Xie, H., Ye, D., Sepich, D., Lin, F. (2016) S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Developmental Biology. 414:228-43
Gu, Y., Shea, J., Slattum, G., Firpo, M.A., Alexander, M., Mulvihill, S.J., Golubovskaya, V.M., Rosenblatt, J. (2015) Defective apical extrusion signaling contributes to aggressive tumor hallmarks. eLIFE. 4:e04069
Ye, D., Xie, H., Hu, B., Lin, F. (2015) Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation. Development (Cambridge, England). 142:2928-40
Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
Nakanaga, K., Hama, K., Kano, K., Sato, T., Yukiura, H., Inoue, A., Saigusa, D., Tokuyama, H., Tomioka, Y., Nishina, H., Kawahara, A., and Aoki, J. (2014) Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. Journal of biochemistry. 155(4):235-41
Hisano, Y., Ota, S., Arakawa, K., Muraki, M., Kono, N., Oshita, K., Sakuma, T., Tomita, M., Yamamoto, T., Okada, Y., and Kawahara, A. (2013) Quantitative assay for TALEN activity at endogenous genomic loci. Biology Open. 2(4):363-367
Hisano, Y., Ota, S., Takada, S., and Kawahara, A. (2013) Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development. Biology Open. 2(8):789-794

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