Gene

thrb

ID
ZDB-GENE-990415-268
Name
thyroid hormone receptor beta
Symbol
thrb Nomenclature History
Previous Names
  • thr2 (1)
  • trb
  • fj24f03
  • NR1A2 (1)
  • nr1a2 (1)
  • TR[b]1 (1)
  • wu:fj24f03 (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Exhibits nuclear receptor activity. Involved in regulation of transcription, DNA-templated; sensory organ development; and thyroid hormone mediated signaling pathway. Predicted to localize to RNA polymerase II transcription factor complex. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Is expressed in several structures, including brain; eye; heart; liver; and optic vesicle. Orthologous to human THRB (thyroid hormone receptor beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With thrb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
selective pituitary thyroid hormone resistance Alliance Thyroid hormone resistance, selective pituitary 145650
thyroid hormone resistance syndrome Alliance Thyroid hormone resistance 188570
thyroid hormone resistance syndrome Alliance Thyroid hormone resistance, autosomal recessive 274300
Associated With thrb Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR001728 Thyroid hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Thyroid hormone receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q9PVE4 395
UniProtKB:A0A2R8QK91 508
UniProtKB:J9JI02 122
UniProtKB:S6BPQ3 488
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations