Gene

thraa

ID
ZDB-GENE-990415-263
Name
thyroid hormone receptor alpha a
Symbol
thraa Nomenclature History
Previous Names
  • thr1 (1)
  • thra
  • thral
  • TR[a]1 (1)
  • tra1
  • tra
  • c-erbA (1)
  • NR1A1-A (1)
  • nr1a1
  • nr1a1a (1)
  • wu:fb59g07
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Exhibits nuclear receptor activity. Involved in several processes, including regulation of transcription by RNA polymerase II; thyroid hormone mediated signaling pathway; and ventricular system development. Localizes to nucleus. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Is expressed in several structures, including blastodisc; muscle; nervous system; optic cup; and pleuroperitoneal region. Orthologous to human THRA (thyroid hormone receptor alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With thraa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nongoitrous hypothyroidism 6 Alliance Hypothyroidism, congenital, nongoitrous, 6 614450
Associated With thraa Via Experimental Models
Human Disease Fish Conditions Citations
hypothyroidism AB + MO4-thraa standard conditions Marelli et al., 2016
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR001728 Thyroid hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Thyroid hormone receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q98867 427
UniProtKB:O42559 41
UniProtKB:O42558 28
UniProtKB:I3ISF8 409
UniProtKB:B2GQG7 427
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations