FIGURE

Fig 2

ID

ZDB-FIG-260710-10

Publication

Williams-Ward et al., 2026 - Yap1 regulates motility and vertebral development and prevents kyphoscoliosis in zebrafish

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Fig 2

Wwtr1 mutants are defective in evoked motility.
(A) Muscle growth analysed in sibling wild type (wt), heterozygote and wwtr1^kg133 mutant bred on the ß-Actin:membEGFP background and reared at 28.5ºC until 5 dpf and then at 26.5ºC to the indicated age. Wwtr1^kg133 mutants and their siblings have similar muscle growth. Note that apparent gaps (asterisks) between fibres reflect reporter mosaicism, not absence of fibres. Bar = 50 μm. (B) Fish movement in response to electrical stimulation under anaesthetic was reduced in wwtr1^kg169 mutants compared to siblings. Bar = 500 μm. (C,D). Swim velocity in response to touch stimulation at 5 dpf (C) and 11 dpf (D). Number of fish analysed is indicated on columns. Significant statistical results are shown (A-D) for Kruskal-Wallis tests with Dunn’s post hoc comparisons, with the exception of the highly significant main effect of age is in A.

Expression Data

Gene:	EGFP
Fish:	wwtr1^kg133/kg133; pc21Tg/pc21Tg
Anatomical Term:	muscle
Stage Range:	Prim-5 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wwtr1^kg169/kg169 wwtr1^kg169/+ wwtr1^kg133/+; pc21Tg/pc21Tg wwtr1^kg133/kg133; pc21Tg/pc21Tg
Condition:	mechanical stress
Observed In:	muscle swimming behavior thigmotaxis
Stage Range:	Prim-5 to Days 7-13

Phenotype Detail

Acknowledgments

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