IMAGE

Fig 2

ID

ZDB-IMAGE-260710-12

Genes

EGFP

Publication

Williams-Ward et al., 2026 - Yap1 regulates motility and vertebral development and prevents kyphoscoliosis in zebrafish

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Figures for Williams-Ward et al., 2026

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Figure Caption

Fig 2 Wwtr1 mutants are defective in evoked motility.
(A) Muscle growth analysed in sibling wild type (wt), heterozygote and wwtr1^kg133 mutant bred on the ß-Actin:membEGFP background and reared at 28.5ºC until 5 dpf and then at 26.5ºC to the indicated age. Wwtr1^kg133 mutants and their siblings have similar muscle growth. Note that apparent gaps (asterisks) between fibres reflect reporter mosaicism, not absence of fibres. Bar = 50 μm. (B) Fish movement in response to electrical stimulation under anaesthetic was reduced in wwtr1^kg169 mutants compared to siblings. Bar = 500 μm. (C,D). Swim velocity in response to touch stimulation at 5 dpf (C) and 11 dpf (D). Number of fish analysed is indicated on columns. Significant statistical results are shown (A-D) for Kruskal-Wallis tests with Dunn’s post hoc comparisons, with the exception of the highly significant main effect of age is in A.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.