FIGURE

Fig. 2

ID

ZDB-FIG-251016-80

Publication

Guerra et al., 2025 - Brain accumulation of lactosylceramide characterizes GALC deficiency in a zebrafish model of Krabbe disease

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Fig. 2

Galcb knockout zebrafish exhibits impaired locomotion behaviour. (A) Representative swim behaviour tracking for wild-type (WT) and galcb knockout (KO) zebrafish at 4 months post fertilization (mpf). Alterations of fish locomotion of galcb KO mutants versus WT siblings was recorded for 5 min from the side view of the tank and quantified by measuring the number of body rotation/min (B) and total distance moved (C) using the Ethovision software equipped with a colour camera (five animals/group). Data are the mean ± standard error of the mean. Student's t-test: *P < 0.05, **P < 0.01. (D) Time frame images from Supplementary Video 1 showing the swim behaviour of WT and galcb KO zebrafish at 4 mpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	galcb^{ubx102/ubx102} (AB)
Observed In:	swimming behavior
Stage:	Adult

Phenotype Detail

Acknowledgments

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