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Fig 3

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ZDB-FIG-250906-80

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He et al., 2025 - Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice

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Fig 3

Kif15 deficiency affects the expression of Gephyrin and GABRB1 in PFC and hippocampus.

A-C: Western blot analysis of inhibitory postsynaptic proteins expression in 3, 6 and 11 week-old Kif15^+/+ and Kif15^-/- mice in PFC. G-I: Western blot analysis of inhibitory postsynaptic proteins expression in 3, 6 and 11 week-old Kif15^+/+ and Kif15^-/- mice in Hippocampus. D and J: Similar expression of gephyrin between two groups at 3 week-old in both PFC and hippocampus, n = 6 mice in each group. E and K: Increased gephyrin or GABRB1 expression in Kif15^-/- mice compared with Kif15^+/+ mice at 6 week-old in PFC and hippocampus, n = 6 mice in each group. F and L: High expression of gephyrin and GABRB1 in Kif15^-/- mice compared with Kif15^+/+ mice in PFC and hippocampus, n = 6 mice in each group. All the data are presented as mean±SD, *P < 0.05, **P < 0.01, two-tailed student’s t test were used for comparison between two groups, expect for the GABRB1 of E, which was used as a nonparametric test.

Expression Data

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Phenotype Data

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