FIGURE

Fig 2

ID

ZDB-FIG-250906-79

Publication

He et al., 2025 - Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice

Other Figures

All Figure Page

Back to All Figure Page

Fig 2

Kif15 deficiency affects the expression of excitatory postsynaptic receptors in PFC and hippocampus.

(A and D): Western Blot analysis showed decreased protein levels of PSD95 and NMDA receptor GluN2A in the PFC of 3 week-old Kif15^-/- mice, n = 7 ~ 8 in Kif15^+/+ group, n = 6 in Kif15^-/- group. (B and E): Decreased expression of PSD95 in the PFC at 6 week-old Kif15^-/- group mice, n = 6 in Kif15^+/+ group, n = 8 in Kif15^-/- group. (C and F): Increased expression of PSD95 in the PFC of Kif15^-/- group compared with Kif15^+/+ group mice at 11 week-old, n = 7 in each group. (G and J): The expression of PSD95 in hippocampus of Kif15^-/- mice decreased at 3 weeks, n = 8 in Kif15^+/+group, n = 6 in Kif15^-/- group (H and K): The expression of PSD95 and GluN2A in hippocampus of Kif15^-/- mice was lower than that of wild type mice at 6 weeks, n = 6 in Kif15^+/+ group, n = 8 in Kif15^-/- group. (I and L): The expression of PSD95, GluA1 and GluN2A in the hippocampus of Kif15^-/- mice was significantly higher than that of Kif15 WT mice at 11 weeks, n = 7 in each group. All the data are presented as mean±SD, *P < 0.05, **P < 0.01, two-tailed student’s t test were used for comparison between two groups, expect for the GluA1 of J, which was used as a nonparametric test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.