FIGURE

Fig. 5

ID

ZDB-FIG-250729-92

Publication

Wu et al., 2025 - Mitochondrial dysfunction is driven by imbalanced fission and fusion of mitochondria in myofibrillar myopathy type 5

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Fig. 5

Flnc deficiency resulted in impaired mitochondrial dynamics. (A) Colocalization of F-actin, filamin-C, and Drp1 in wild-type zebrafish. (B) Coimmunoprecipitation of actin and Drp1 from lysates from MO and COMO zebrafish. IgG was used as an IP negative control. The data showed that the ability of Drp1 to bind to actin was weakened in the MO zebrafish. (C) Compared with the CoMO group, the MO group exhibited significantly increased expression of Drp1 and Opa1. All the data are shown as the means ± SDs. *P < 0.05, **P < 0.01, ***P < 0.001. Statistical significance was calculated via Student’s two-tailed t test.

Expression Data

Genes:	dnm1l fis1 mfn2 opa1
Antibodies:	Ab1-flnc Ab4-dnm1l
Fish:	WT WT + MO1-flnca + MO2-flncb
Knockdown Reagents:	MO1-flnca MO2-flncb
Anatomical Terms:	skeletal muscle cell whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-flnca + MO2-flncb
Knockdown Reagents:	MO1-flnca MO2-flncb
Observed In:	whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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