Gene
mfn2
- ID
- ZDB-GENE-081105-44
- Name
- mitofusin 2
- Symbol
- mfn2 Nomenclature History
- Previous Names
-
- mg:cb01g09
- si:dkeyp-104h9.2
- wu:fb79a11
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Acts upstream of or within several processes, including axonal transport of mitochondrion; axonogenesis; and neuromuscular junction development. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including heart; muscle; nervous system; otic vesicle; and ventral mesenchyme. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2A2A | Alliance | Charcot-Marie-Tooth disease, axonal, type 2A2A | 609260 |
| Charcot-Marie-Tooth disease type 2A2B | Alliance | Charcot-Marie-Tooth disease, axonal, type 2A2B | 617087 |
| Charcot-Marie-Tooth disease type 6 | Alliance | Hereditary motor and sensory neuropathy VIA | 601152 |
| multiple symmetric lipomatosis | Alliance | Lipomatosis, multiple symmetric, with or without peripheral neuropathy | 151800 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2 | ml2Tg + MO1-mfn2 | standard conditions | Vettori et al., 2011 |
| Charcot-Marie-Tooth disease type 2 | WT + MO1-mfn2 | standard conditions | Vettori et al., 2011 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamin, N-terminal | Dynamin-type guanine nucleotide-binding (G) domain | Fzo/mitofusin HR2 domain | Mitofusin family | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BJP0 | InterPro | 757 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-104H9 | ZFIN Curated Data | |
| Contains | SNP | rs3728186 | ZFIN Curated Data | |
| Encodes | EST | cb01g09 | ||
| Encodes | EST | fb79a11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128254 (1) | 5370 nt | ||
| Genomic | GenBank:BX548250 (2) | 165603 nt | ||
| Polypeptide | UniProtKB:A0A8M2BJP0 (1) | 757 aa |
- Grepper, D., Tabasso, C., Zanou, N., Aguettaz, A.K.F., Castro-Sepulveda, M., Ziegler, D.V., Lagarrigue, S., Arribat, Y., Martinotti, A., Ebrahimi, A., Daraspe, J., Fajas, L., Amati, F. (2024) BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function. iScience. 27:110510110510
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Ruparelia, A.A., Montandon, M., Merriner, J., Huang, C., Wong, S.F.L., Sonntag, C., Hardee, J.P., Lynch, G.S., Miles, L.B., Siegel, A., Hall, T.E., Schittenhelm, R.B., Currie, P.D. (2024) Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP. JCI insight. 9(8):
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Chen, A.Q., Xue, M., Qiu, C.Z., Zhang, H.Y., Zhou, R., Zhang, L., Yin, Z.J., Ren, D.L. (2023) Circadian clock1a coordinates neutrophil recruitment via nfe212a/duox-reactive oxygen species pathway in zebrafish. Cell Reports. 42:113179113179
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530
- Zhang, R., Tu, Y.X., Ye, D., Gu, Z., Chen, Z.X., Sun, Y. (2022) A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(36):e2203631
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
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