Gene
dnm1l
- ID
- ZDB-GENE-040426-1556
- Name
- dynamin 1-like
- Symbol
- dnm1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including intracellular distribution of mitochondria; mitochondrion organization; and peroxisome fission. Predicted to act upstream of or within rhythmic process. Predicted to be located in cytosol; mitochondrial outer membrane; and peroxisome. Predicted to be active in membrane; microtubule; and mitochondrion. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| encephalopathy due to defective mitochondrial and peroxisomal fission 1 | Alliance | Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 | 614388 |
| optic atrophy 5 | Alliance | Optic atrophy 5 | 610708 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamin | Dynamin, GTPase domain | Dynamin GTPase effector | Dynamin, GTPase region, conserved site | Dynamin, N-terminal | Dynamin stalk domain | Dynamin-type guanine nucleotide-binding (G) domain | GTPase effector domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BA46 | InterPro | 703 | |||||||||
| UniProtKB:Q7SXN5 | InterPro | 691 | |||||||||
| UniProtKB:A0A140LH30 | InterPro | 715 | |||||||||
| UniProtKB:A0A8M2BAD6 | InterPro | 727 |
1 - 4 of 4
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available