FIGURE

Fig. 2

ID

ZDB-FIG-250131-49

Publication

Li et al., 2024 - Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway

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Fig. 2

Human DLG5 over-expression prevent phenylhydrazine (PHZ)-induced zebrafish thrombosis. (a–l) Representative images of Tg (CD41: GFP) zebrafish embryos at 3-dpf treated with WT control (empty vector), human DLG5, WT control plus PHZ (2 μM) or human DLG5 plus PHZ (2 μM). Zebrafish at 2-dpf treated with 2-μM PHZ for 24 h visually showed severe thrombosis and platelet aggregation in the caudal vessels (c,g,k, red arrows) without observable toxicity. (c,d,g,h) Compared with PHZ treated group, human DLG5 over-expression prevent PHZ-induced zebrafish thrombosis. (m) Quantification of the average number of thrombocyte (GFP+) at caudal vein. Columns, mean; bars, SEM (n = 10; ANOVA; * P < 0.05). dpf, days post fertilization; PHZ, phenylhydrazine.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Br. J. Pharmacol.