FIGURE

Fig. 3

ID

ZDB-FIG-250131-50

Publication

Li et al., 2024 - Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway

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Fig. 3

Effect of human DLG5 over-expression on signalling pathways in zebrafish. (a) Endogenous mpl, itga2b (ITGA2B), itgb3b (ITGB3), tubb1, wasb (WAS), actn1, myh9a (MYH9), gp1bb, gp9, flna, prkacaa, vwf, nbeal2, cycsa (CYCS), abcg5, abcg8, dlg5a (DLG5), mst1, stk3 (MST2), lats1, lats2, yap1 (YAP) and taz in WT control (empty vector) and human DLG5 injected embryos assessed by qRT-PCR (n = 10 individual embryos). * P < 0.05. (b) DLG5 over-expression causes changes in expression levels of ‘genes’ involved in MK growth, differentiation and maturation. The red and blue arrows colours indicate upregulated and downregulated molecules, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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