FIGURE

Fig.8

ID

ZDB-FIG-250122-67

Publication

Ranard et al., 2024 - Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment

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Fig.8

Offspring with low DHA status have dysregulated vision and stress response gene pathways. Morphologically normal 4 dpf larvae from wild-type mothers fed a DHA-sufficient diet (WT-SUFF) or elovl2^+/−mothers fed a DHA-deficient diet (elovl2-DEF) were used for bulk RNA-seq (n = 3 replicates/group, n = 25 pooled whole larvae/replicate). A: Principal component analysis shows that samples in the same group cluster together. B: Volcano plot of differentially expressed genes in elovl2-DEF compared to WT-SUFF (290 genes). Dashed lines mark thresholds used to assess statistical significance (FDR-adjusted P-value <0.1, ≥ 2 fold change). C: Significantly down- (maroon) and up- (coral) regulated gene pathways identified from a Metascape pathway enrichment analysis using the 290 DEGs (hypergeometric test with Benjamini-Hochberg procedure for multiple comparisons).

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Lipid Res.