FIGURE

Fig 6

ID

ZDB-FIG-231215-205

Publication

Maung Ye et al., 2023 - A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration

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Fig 6

Hemodynamics adaptation scenarios for Marcksl1 OE and Marcksl1 KO.

(A) WT levels of RBC (i) and systolic blood pressure (ii) distribution, see S1 Movie. (B) Marcksl1 OE model (ML1OE) with same blood pressure boundary conditions (BCs) at anterior/posterior input locations as WT. Spatial maps of RBC perfusion (Bi) and systolic blood pressure distribution (Bii) where yellow dashed circles indicate the locally dilated lumen region compared to WT (Bi), see S7 Movie. Dashed red box region in Aii and Bii is the local network region where pressure distribution has been altered between WT and ML1OE. (C—E) Marcksl1 KO Model 1 (ML1KO1, C) with reduced blood pressure BCs, Marcksl1 KO Model 2 (ML1KO2, D) with same blood pressure BCs as WT and Marcksl1 KO Model 3 (ML1KO3, E) with increased blood pressure BCs. Spatial maps of RBC perfusion (i) and systolic blood pressure distribution (ii), see S8–S10 Movies.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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