FIGURE

Figure 4

ID

ZDB-FIG-231023-8

Publication

Deng et al., 2023 - Ypel5 regulates liver development and function in zebrafish

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Figure 4

Hnf4a acts as a crucial downstream effector of Ypel5. (A and B) ChEA3 transcription factor (TF) analysis was performed on differentially expressed genes. The top 10 proteins and their co-regulatory networks are shown. (C and D) Western blot analysis of HNF4A in Huh-7 cells. (E) qPCR analysis of hnf4a expression in control siblings and ypel5^−/− mutants at 3 dpf. (F and G) WISH assay of fabp10a (F) and relative liver size (G) of zebrafish larvae at 7.5 dpf. Green lines circle the boundary of the liver. (H) qPCR analysis of genes related to cholesterol metabolism and complement and coagulation cascades. Data shown are mean ± SEM. Student's t-test. **P < 0.01; ***P < 0.001.

Expression Data

Genes:	apoa1a apoa1b apoa2 apoea apoeb cfb cfh cfi cyp7a1 fga fgb fgg hnf4a serpinc1
Fish:	WT ypel5^rj110/rj110
Anatomical Term:	whole organism
Stage Range:	Protruding-mouth to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ypel5^rj110/rj110
Observed In:	liver whole organism
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Mol. Cell Biol.