Gene

cyp7a1

ID
ZDB-GENE-040426-1296
Name
cytochrome P450, family 7, subfamily A, polypeptide 1
Symbol
cyp7a1 Nomenclature History
Previous Names
  • cyp7a1
  • cyp7a1a
  • zgc:63920 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cellular response to glucose stimulus and cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in basal plate midbrain region; central nervous system; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Enya et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp7a1 Human Ortholog
No data available
Associated With cyp7a1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002403 Cytochrome P450, E-class, group IV
Family IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
Family IPR030681 Cholesterol 7-alpha-monooxygenase
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cholesterol 7-alpha-monooxygenase Cytochrome P450 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type Cytochrome P450, conserved site Cytochrome P450, E-class, group IV Cytochrome P450 superfamily
UniProtKB:F1QU76 512
UniProtKB:Q7T2F3 512
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations