Gene
apoa1b
- ID
- ZDB-GENE-050302-172
- Name
- apolipoprotein A-Ib
- Symbol
- apoa1b Nomenclature History
- Previous Names
-
- wu:fb66d03
- wu:fd19c08
- xx:sd49
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have cholesterol binding activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Predicted to localize to chylomicron and high-density lipoprotein particle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia; non-alcoholic steatohepatitis; and systemic lupus erythematosus. Is expressed in blood; liver; otolith; and yolk syncytial layer. Orthologous to human APOA1 (apolipoprotein A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial visceral amyloidosis | Alliance | Amyloidosis, 3 or more types | 105200 |
| primary hypoalphalipoproteinemia 2 | Alliance | Hypoalphalipoproteinemia, primary, 2 | 618463 |
| Hypoalphalipoproteinemia, primary, 2, intermediate | 619836 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000074 | Apolipoprotein A/E |
Domain Details Per Protein
| Protein | Length | Apolipoprotein A/E |
|---|---|---|
|
UniProtKB:A0A0R4IKF0
|
257 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids