FIGURE

Fig 5

ID

ZDB-FIG-231013-5

Publication

Sakata et al., 2023 - Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium

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Fig 5

ACh dose–response relationships of the chimeric receptors.

(A), (B), (C), (D), (E), (F), (G), (H), Dose dependency of ACh currents recorded from oocytes co-injected with α, β, δ and the chimeric subunit. Data points are shown as mean ± sem. Current amplitudes were normalized by the current elicited by 100 μM ACh. (I), EC₅₀s of AChRs containing chimeric subunits. Points and bars indicate EC₅₀ from individual oocytes and the means, respectively. Error bars indicate SEM (N = 6 for the ε-type, N = 5 for the δ-type, N = 5 for the δ/ε/ε, N = 5 for the ε/δ/δ, N = 5 for the δ/ε/δ, N = 6 for the ε/δ/ε, N = 5 for the ε/ε/δ, N = 6 for the δ/δ/ε).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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