FIGURE

FIGURE 9

ID

ZDB-FIG-231002-233

Publication

Meier et al., 2023 - Zebrafish as model system for the biological characterization of CK1 inhibitors

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FIGURE 9

Modelling of the interaction of the SMI G2-2 with human CK1δ and the zebrafish CK1δ variants (A, B). Ligand-protein models of G2-2 with human CK1δ (PDB code 5OKT) (A), zebrafish CK1δA (B) and zebrafish CK1δB (C) were generated using Schrödinger Maestro. Hydrogen bonds between the inhibitor and the respective kinase are shown in dashed lines. (D) Exemplary 2D ligand interaction diagram of zebrafish CK1δA with G2-2. The hydrogen bonds are shown as purple arrows.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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