FIGURE

Figure 6.

ID

ZDB-FIG-230622-29

Publication

Kanyo et al., 2023 - Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels

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Figure 6.

ML252 modifies neuronal activity in zebrafish larvae, and is selectively weakened by the pore-targeted activator ML213. (A) Exemplar images of zebrafish larvae (dorsal view) with neuronal-specific expression of CaMPARI. PC (leading to a higher magenta signal) indicates higher neuronal activity, whereas the absence of PC (weaker magenta signal) indicates low neuronal activity. (B) Summary of PC (red/green ratio) observed in zebrafish larvae treated with ML252 alone or in combination with either ML213 or ICA-069673. Intensities of red (R) and green (G) fluorescence emissions are displayed as red to green ratio and normalized to DMSO controls (quantified in the hindbrain area, dashed white line in panel A) (n = 7–9 larvae per condition). * indicates statistical significance vs. ML252 alone (ANOVA followed by Dunn’s post-hoc test, P < .01).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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