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Fig. 1

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ZDB-FIG-230518-80

Publication

Doboszewska et al., 2023 - TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice

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Fig. 1

Experimental paradigm in mice. a Swiss Albino mice or C57BL/6/Tar × CBA/Tar GPR39 knockout and wild-type mice were subjected to acute models of electrically or chemically induced seizures or a chronic model of epileptogenesis [chemical kindling induced by pentylenetetrazole (PTZ)], followed by observation of seizure behavior. Animals were pre-treated with agonists of GPR39: the small molecule TC-G 1008 or ZnCl₂ or a standard anti-seizure drug, valproic acid (VPA), i.p. b Detailed mouse allocation in each of the experimental procedures

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