FIGURE

FIGURE 4

ID

ZDB-FIG-230515-50

Publication

Dorigo et al., 2023 - Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner

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FIGURE 4

Formation of functional domains in the Purkinje cell (PC) population is impaired upon inhibiting PC neuronal activity. The pie charts represent the percentage of Optovin-induced swimming-correlated Ca²⁺ transients from 4 to 6 dpf localized in different regions of the PC layer. Ca²⁺ transients were recorded after continuous Arch3-stimulating illumination to suppress PC activity in (A) Tg(ca8-E1B:FMATagRFP,GCaMP5G)^bz6 larvae as control and (B) Arch3-expressing Tg(ca8-E1B:Hso.Arch3-TagRFPT,GCaMP5G)^bz5 larvae. n represents number of recorded Ca²⁺ transients/number of larvae. The number of transients per larvae in each PC subregion in (C) control and (D) Arch3-expressing larvae is displayed for consecutive days during which PC maturation occurs. The data are represented as mean ± SEM. Kruskal-Wallis test followed by Dunn’s multiple comparisons test was used in (C). Denotations for significance is *p < 0.0332.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.