FIGURE

Figure 5

ID

ZDB-FIG-230406-87

Publication

Rolland et al., 2022 - The regenerative response of cardiac interstitial cells

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Figure 5

MMP14-expressing macrophages are required for cardiac regeneration. (A) Schematic of the inhibitor treatment protocol. (B and D) AFOG staining of a control (B) or NSC405020-treated (D) heart at 30 dpa. The black dashed line indicates the plane of amputation. Scale bar, 200 μm. (C and E) The same images as in B and D are shown at higher magnification, respectively. Note the presence of a large fibrin (red)/collagen (blue) scar. Scale bar, 100 μm. (F) The graph indicates the average area of the wound region as a percentage of the entire ventricle (n = 9). (G and H) EdU labelling of cycling cardiomyocytes in a control (G) or NSC405020-treated (H) heart. MEF2/cardiomyocytes (red), EdU (green). The dashed white box indicates the area shown at higher magnification in the inset. Scale bar, 200 μm.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Mol. Cell Biol.