PUBLICATION
The regenerative response of cardiac interstitial cells
- Authors
- Rolland, L., Harrington, A., Faucherre, A., Abaroa, J.M., Gangatharan, G., Gamba, L., Severac, D., Pratlong, M., Moore-Morris, T., Jopling, C.
- ID
- ZDB-PUB-221023-5
- Date
- 2022
- Source
- Journal of molecular cell biology 14(10): (Journal)
- Registered Authors
- Faucherre, Adele, Jopling, Chris
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Proliferation
- Humans
- Myocardial Infarction*
- Myocytes, Cardiac*
- Zebrafish
- PubMed
- 36271843 Full text @ J. Mol. Cell Biol.
Citation
Rolland, L., Harrington, A., Faucherre, A., Abaroa, J.M., Gangatharan, G., Gamba, L., Severac, D., Pratlong, M., Moore-Morris, T., Jopling, C. (2022) The regenerative response of cardiac interstitial cells. Journal of molecular cell biology. 14(10):.
Abstract
Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial infarction. Currently, it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac regeneration. To understand how interstitial cells behave during this process, we performed single-cell RNA sequencing (scRNA-seq) of regenerating zebrafish hearts. Using a combination of immunohistochemistry, chemical inhibition, and novel transgenic animals, we were able to investigate the role of cell type-specific mechanisms during cardiac regeneration. This approach allowed us to identify a number of important regenerative processes within the interstitial cell populations. Here, we provide detailed insight into how interstitial cells behave during cardiac regeneration, which will serve to increase our understanding of how this process could eventually be induced in humans.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping