FIGURE

Figure 2

ID

ZDB-FIG-221118-15

Publication

Ha et al., 2022 - Neurotoxicity of diesel exhaust extracts in zebrafish and its implications for neurodegenerative disease

Other Figures

All Figure Page

Back to All Figure Page

Figure 2

Microglial activation with DEPe exposure. Maximum branch length was significantly shorter (A), fewer numbers of branches (B) and fewer junctions (C) with DEPe exposure. Student’s T-test, **p < 0.01, ****p < 0.0001, n = 11, 11 (DMSO, DEPe). Dorsal view of 5dpf mpeg1:mCherry ZF brains revealing that control microglia (D) had more processes and were less rounded than DEPe-treated cells (E). Whole-body expression of pro-inflammatory cytokines with DEPe exposure, IL-1b expression was significantly upregulated compared to DMSO (F). There were no significant changes in expression of pro-inflammatory cytokines with DEPe exposure in the heads of ZF (G). For F and G, one-way ANOVA with Dunnett’s test, ***p < 0.001, n = 5 samples. Significantly more microglial cells colocalized with lysotracker-labeling 5dpf in DEPe-treated microglia (H,J) compared to DMSO-treated controls (H,I). Student’s T-test, ***p < 0.001, n = 10, 7.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.