FIGURE

Figure 6

ID

ZDB-FIG-221104-58

Publication

Crouzier et al., 2022 - NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome

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Figure 6

Ncs1 overexpression restores the mitochondrial function

(A) OCR in mCherry- or Ncs1 RNA-injected wfs1ab^WT and wfs1ab^KO zebrafish larvae at 5 dpf. (B) Basal respiration, (C) ATP production-related OCR, (D) maximal respiration, (E) proton leak, and (F) non-mitochondrial respiration. Data in (A–F) are mean ± SEM calculated from the number of animals indicated below the columns in (B), n = 26 animals wfs1ab^WT mcherry, n = 35 animals wfs1ab^KO mcherry, n = 27 animals wfs1ab^WT Ncs1, n = 36 animals wfs1ab^KO Ncs1. ∗p < 0.05 versus wfs1ab^WT, ^##p < 0.01 versus mCherry RNA treatment; Tukey’s multiple comparison test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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