FIGURE

Fig. 6

ID

ZDB-FIG-220926-6

Publication

Jussila et al., 2022 - Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2

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Fig. 6

Degradation of sfGFP-Vangl2 in foxj1a-positive cell lineages causes embryonic axial curvature and postembryonic idiopathic-like scoliosis.

Overview of body axis phenotypes observed in control (a) and vangl2^sfGFP/sfGFP;Tg(βactin2::loxP-mCherry-STOP-loxP-zGrad);Tg(foxj1a::iCre) embryos (b–e) at 3 dpf. Lateral and dorsal projections of 3-dimensional micro-CT scans of 2 month old control (f) and vangl2^sfGFP/sfGFP;Tg(βactin2::loxP-mCherry-STOP-loxP-zGrad);Tg(foxj1a::iCre) fish (g–i).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vangl2^{hsc170Tg/hsc170Tg}; hsc105bTg/+; hsc185Tg/+ (TU) vangl2^{hsc170Tg/hsc170Tg}; hsc185Tg/+ (TU)
Observed In:	post-vent region vertebral column whole organism anterior-posterior axis
Stage Range:	Protruding-mouth to Days 45-89

Phenotype Detail

Acknowledgments

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