FIGURE

Fig. 7

ID

ZDB-FIG-220607-36

Publication

Varela et al., 2022 - Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder

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Fig. 7

Molecular analysis of cdkl5^sa21938 mutants. Relative gene expression analysis of neuronal markers (A), including glutamatergic neurotransmission markers (B) in wild-type (WT), heterozygous (cdkl5^+/−), and homozygous (cdkl5^−/−) mutant zebrafish embryos at 5 dpf, measured by qPCR. For bdnf, mecp2, gria2b and grin1b, values are presented as mean ± SD and statistical analysis was performed using one-way ANOVA followed by Tukey’s test. For mef2ca, drd2a, grim1b and slc1a1, data are presented as median with interquartile range and statistical analysis was performed using Kruskal–Wallis followed by Dunn multiple comparisons test. At least three independent experiments were performed. *, and ** indicate p < 0.05 and p < 0.01, respectively. ns indicates not significant.

Expression Data

Genes:	bdnf drd2a gria2b grin1b grm1b mecp2 mef2ca slc1a1 (all 8)
Fish:	AB cdkl5^{sa21938/sa21938} (AB) cdkl5^sa21938/+ (AB)
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cdkl5^{sa21938/sa21938} (AB) cdkl5^sa21938/+ (AB)
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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