Gene
slc1a1
- ID
- ZDB-GENE-040718-414
- Name
- solute carrier family 1 member 1
- Symbol
- slc1a1 Nomenclature History
- Previous Names
-
- EAAT3 (1)
- zgc:91959
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable L-glutamate transmembrane transporter activity; cysteine transmembrane transporter activity; and glutamate:sodium symporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in several cellular components, including apical plasma membrane; endosome membrane; and neuron projection. Predicted to be active in plasma membrane. Is expressed in cerebellum; optic tectum; and telencephalon. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nv1211 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
1 - 1 of 1
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dicarboxylic aminoaciduria | Alliance | Dicarboxylic aminoaciduria | 222730 |
| schizophrenia 18 | Alliance | {?Schizophrenia susceptibility 18} | 615232 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dicarboxylate/Amino Acid:Cation Symporter | Sodium:dicarboxylate symporter | Sodium:dicarboxylate symporter, conserved site | Sodium:dicarboxylate symporter superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:D7RVR6 | InterPro | 528 | ||||
| UniProtKB:A0A8M9QGS6 | InterPro | 329 | ||||
| UniProtKB:Q6DG02 | InterPro | 526 |
1 - 3 of 3
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
slc1a1-202
(1)
|
Ensembl | 779 nt | ||
| mRNA |
slc1a1-201
(1)
|
Ensembl | 2,966 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-243H6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91959 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191148 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002666 (1) | 2860 nt | ||
| Genomic | GenBank:CU672220 (2) | 42846 nt | ||
| Polypeptide | UniProtKB:D7RVR6 (1) | 528 aa |
- Varela, T., Varela, D., Martins, G., Conceição, N., Cancela, M.L. (2022) Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 12:9325
- Hentig, J., Campbell, L.J., Cloghessy, K., Lee, M., Boggess, W., Hyde, D.R. (2021) Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2a. Biomedicines. 10(1):
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Wang, J., Jia, B., Li, Y., Ren, B., Liang, H., Yan, D., Xie, H., Zhang, X., Liang, H. (2020) Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio). Journal of hazardous materials. 397:122724
- Liu, H., Liu, Z.Z. (2019) Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome. Behavioural brain research. 378:112293
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Gesemann, M., Lesslauer, A., Maurer, C.M., Schönthaler, H.B., and Neuhauss, S.C. (2010) Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific subfamilies. BMC Evolutionary Biology. 10:117
- Gesemann, M., Maurer, C.M., and Neuhauss, S.C. (2010) Excitatory amino acid transporters in the zebrafish: Letter to "Expression and functional analysis of Na(+)-dependent glutamate transporters from zebrafish brain" from Rico et al. Brain research bulletin. 83(5):202-206
- Rico, E.P., de Oliveira, D.L., Rosemberg, D.B., Mussulini, B.H., Bonan, C.D., Dias, R.D., Wofchuk, S., Souza, D.O., and Bogo, M.R. (2010) Expression and functional analysis of Na(+)-dependent glutamate transporters from zebrafish brain. Brain research bulletin. 81(4-5):517-523
1 - 10 of 11
Show