Gene
slc1a1
- ID
- ZDB-GENE-040718-414
- Name
- solute carrier family 1 member 1
- Symbol
- slc1a1 Nomenclature History
- Previous Names
-
- EAAT3 (1)
- zgc:91959
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable L-glutamate transmembrane transporter activity; cysteine transmembrane transporter activity; and glutamate:sodium symporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in several cellular components, including apical plasma membrane; endosome membrane; and neuron projection. Predicted to be active in plasma membrane. Is expressed in cerebellum; optic tectum; and telencephalon. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dicarboxylic aminoaciduria | Alliance | Dicarboxylic aminoaciduria | 222730 |
| schizophrenia 18 | Alliance | {?Schizophrenia susceptibility 18} | 615232 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dicarboxylate/Amino Acid:Cation Symporter | Sodium:dicarboxylate symporter | Sodium:dicarboxylate symporter, conserved site | Sodium:dicarboxylate symporter superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:D7RVR6 | InterPro | 528 | ||||
| UniProtKB:A0A8M9QGS6 | InterPro | 329 | ||||
| UniProtKB:Q6DG02 | InterPro | 526 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
slc1a1-202
(1)
|
Ensembl | 779 nt | ||
| mRNA |
slc1a1-201
(1)
|
Ensembl | 2,966 nt |
Interactions and Pathways
No data available
Plasmids
No data available