Gene

grin1b

ID
ZDB-GENE-051202-2
Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
Symbol
grin1b Nomenclature History
Previous Names
  • NMDAR1.2 (1)
  • si:rp71-1o1.1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Is predicted to contribute to NMDA glutamate receptor activity. Involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Acts upstream of or within ion transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of NMDA selective glutamate receptor complex. Is expressed in brain. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grin1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant non-syndromic intellectual disability 8 Alliance Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 614254
Developmental and epileptic encephalopathy 101 619814
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive 617820
Associated With grin1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001320 Ionotropic glutamate receptor
Domain IPR001828 Receptor, ligand binding region
Domain IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family IPR001508 Ionotropic glutamate receptor, metazoa
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Calmodulin-binding domain C0, NMDA receptor, NR1 subunit Ionotropic glutamate receptor Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Ionotropic glutamate receptor, metazoa Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:B7TWQ4 89
UniProtKB:Q6ZM67 937
UniProtKB:A0A0R4IGA0 879
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations