Gene
bdnf
- ID
- ZDB-GENE-000412-1
- Name
- brain-derived neurotrophic factor
- Symbol
- bdnf Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Acts upstream of or within circadian behavior; multicellular organismal response to stress; and nervous system development. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including blastoderm; digestive system; kidney; nervous system; and oral region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cocaine dependence; cognitive disorder (multiple); congenital central hypoventilation syndrome; and neurodegenerative disease (multiple). Orthologous to human BDNF (brain derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 88 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76834 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-bdnf | (4) | |
| MO1-bdnf | N/A | (6) |
| MO2-bdnf | N/A | Endlich et al., 2018 |
| MO3-bdnf | N/A | Barbereau et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Brain-derived neurotrophic factor | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P735 | InterPro | 278 | |||||
| UniProtKB:Q6NZ01 | InterPro | 270 | |||||
| UniProtKB:A0AB32TV83 | InterPro | 298 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-387L4 | ZFIN Curated Data | |
| Contained in | BAC | CH211-214A19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-251J8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65746 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76834 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76835 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001308649 (1) | 2334 nt | ||
| Genomic | GenBank:AL935207 (2) | 146351 nt | ||
| Polypeptide | UniProtKB:A0AB32TV83 (1) | 298 aa |
- Dhiman, P., Kumar, R., Singh, D. (2025) Neuronal nitric oxide synthase activation by tadalafil protects neurological impairments in a zebrafish larva model of hyperammonemia. Life sciences. 361:123325123325
- Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., Xue, C. (2025) Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos. Food research international (Ottawa, Ont.). 200:115502115502
- Nies, Y.H., Lim, W.L., Abd Karim, N., Yahaya, M.F., Teoh, S.L. (2025) Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson's disease. Frontiers in pharmacology. 16:14780131478013
- Wang, Q., Zhang, L., Zhu, C., Lu, K., Wu, J., Liang, X.F. (2025) Fosab, but not fosaa, plays important role in learning and memory in fish-insights from zebrafish gene knockout study. Frontiers in cell and developmental biology. 13:15030661503066
- Ariani, A., Khotimah, H., Sulistyarini, A., Daniaridevi, A.S. (2024) Centella asiatica extract ameliorates deoxygenation-induced neurological dysfunction in zebrafish larvae. Open veterinary journal. 14:115411601154-1160
- Kalyn, M., Garvey, R., Lee, H., Mbesha, H.A., Curry, J., Saxena, V., Mennigen, J.A., Ekker, M. (2024) Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish. Journal of neurochemistry. :
- Karimi, Z., Zarifkar, A., Mirzaei, E., Dianatpour, M., Dara, M., Aligholi, H. (2024) Therapeutic effects of nanosilibinin in valproic acid-zebrafish model of autism spectrum disorder: Focusing on Wnt signaling pathway and autism spectrum disorder-related cytokines. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 84(5):454-468
- Murugan, R., Ramya Ranjan Nayak, S.P., Haridevamuthu, B., Priya, D., Chitra, V., Almutairi, B.O., Arokiyaraj, S., Saravanan, M., Kathiravan, M.K., Arockiaraj, J. (2024) Neuroprotective potential of pyrazole benzenesulfonamide derivative T1 in targeted intervention against PTZ-induced epilepsy-like condition in in vivo zebrafish model. International Immunopharmacology. 131:111859111859
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Retinasamy, T., Lee, A.L.Y., Lee, H.S., Lee, V.L.L., Shaikh, M.F., Yeong, K.Y. (2024) Repurposing Anakinra for Alzheimer's Disease: The In Vitro and In Vivo Effects of Anakinra on LPS- and AC-Induced Neuroinflammation. ACS Chemical Neuroscience. 15(18):3298-3310
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