Figure 4—figure supplement 1.

Increased cytosine-to-thymine (C-to-T) transition in medaka embryo pools injected with <italic toggle='yes'>heiBE4-Gam</italic>.

(a) Schematic representation of base editing window in OlOca2 T1 target site. (b–c) Sanger sequencing quantifications (EditR; Kluesner et al., 2018) of pools of five randomly picked embryos injected with sgRNA OlOca2 T1 and either BE4-Gam (b) or heiBE4-Gam (c). Note: in heiBE4-Gam injections, for each cytosine, the C-to-T transition rate was higher than 60%, a level never observed in BE4-Gam-injected embryos. C997T is highlighted with white frame.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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