FIGURE

Figure 10.

ID

ZDB-FIG-220505-64

Publication

Egashira et al., 2022 - Spontaneously recycling synaptic vesicles constitute readily releasable vesicles in intact neuromuscular synapses

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Figure 10.

Summary diagram of spontaneous SV fusion at larval zebrafish neuromuscular synapses. Three pools of SVs are depicted: resting pool, recycling pool, and RRP. In the early phase of TTX treatment (<1 h), spontaneous SV fusion is mobilized from the RRP with two distinct modes: virgin exocytosis with a slow time course (τ = 45 min at 25°C) and repeated reuse of the same SVs at a higher rate. The differences between the two modes of fusion are highlighted in the table at bottom. SVs equipped with both canonical and noncanonical v-SNAREs are involved in the two modes, although their dependency on the noncanonical v-SNARE is not identical. They may also be different in their coupling to the voltage-gated Ca²⁺ channels. SVs in RRP are intermixed with those in other pools after a prolonged (>1 h) TTX treatment.

Expression Data

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Antibody Labeling

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurosci.