ZFIN ID: ZDB-FIG-220502-27
Zhang et al., 2020 - Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms   1863(10):194612 Full text @ BBA Gene Regulatory Mechanisms
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Condition:
Knockdown Reagent:
Anatomical Terms:
Stage: Day 4
PHENOTYPE:
Fish:
Condition:
Knockdown Reagent:
Observed In:
Stage Range: Long-pec to Day 4

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
mbpa WT standard conditions Day 4 spinal cord ISH
Day 4 whole organism RTPCR
WT chemical treatment by environment: copper(2+) Day 4 spinal cord RTPCR
WT + MO2-hoxb5b standard conditions Day 4 spinal cord ISH
hoxb5bhza5/hza5 standard conditions Day 4 spinal cord ISH
plp1a WT standard conditions Day 4 spinal cord ISH
Day 4 whole organism RTPCR
WT chemical treatment by environment: copper(2+) Day 4 spinal cord RTPCR
WT + MO2-hoxb5b standard conditions Day 4 spinal cord ISH
hoxb5bhza5/hza5 standard conditions Day 4 spinal cord ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: copper(2+) Day 4 spinal cord mbpa expression decreased amount, abnormal
Day 4 spinal cord plp1a expression decreased amount, abnormal
WT + MO2-hoxb5b standard conditions Long-pec brain hypoplastic, abnormal
Long-pec eye hypoplastic, abnormal
Long-pec trunk morphology, abnormal
Long-pec whole organism decreased size, abnormal
Day 4 spinal cord mbpa expression decreased amount, abnormal
Day 4 spinal cord plp1a expression decreased amount, abnormal
hoxb5bhza5/hza5 standard conditions Long-pec whole organism morphology, normal
Day 4 spinal cord mbpa expression decreased amount, abnormal
Day 4 spinal cord plp1a expression decreased amount, abnormal
vu19Tg + MO2-hoxb5b standard conditions Long-pec central nervous system axon decreased length, abnormal
Full text @ BBA Gene Regulatory Mechanisms