ZFIN ID: ZDB-FIG-220503-3
Zhang et al., 2020 - Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms   1863(10):194612 Full text @ BBA Gene Regulatory Mechanisms
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Conditions:
Anatomical Terms:
Stage Range: Prim-5 to Day 4
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage Range: Prim-5 to Day 4

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed2 vu19Tg standard conditions Long-pec central nervous system RTPCR
vu19Tg chemical treatment by environment: copper(2+) Long-pec central nervous system RTPCR
vu19Tg chemical treatment by environment: copper(2+), chemical treatment by environment: 6-bromoindirubin-3'-oxime Long-pec central nervous system RTPCR
hoxb5b WT standard conditions Prim-5 trunk ISH
WT chemical treatment by environment: copper(2+) Prim-5 trunk ISH
WT chemical treatment by environment: copper(2+), chemical treatment by environment: 6-bromoindirubin-3'-oxime Prim-5 trunk ISH
mbpa WT standard conditions Day 4 central nervous system ISH
WT chemical treatment by environment: copper(2+) Day 4 central nervous system ISH
WT chemical treatment by environment: copper(2+), chemical treatment by environment: 6-bromoindirubin-3'-oxime Day 4 central nervous system ISH
plp1a WT standard conditions Day 4 central nervous system ISH
WT chemical treatment by environment: copper(2+) Day 4 central nervous system ISH
WT chemical treatment by environment: copper(2+), chemical treatment by environment: 6-bromoindirubin-3'-oxime Day 4 central nervous system ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: copper(2+) Prim-5 trunk hoxb5b expression decreased amount, abnormal
Day 4 central nervous system mbpa expression decreased amount, abnormal
Day 4 central nervous system plp1a expression decreased amount, abnormal
WT chemical treatment by environment: copper(2+), chemical treatment by environment: 6-bromoindirubin-3'-oxime Prim-5 trunk hoxb5b expression amount, ameliorated
Day 4 central nervous system mbpa expression amount, ameliorated
Day 4 central nervous system plp1a expression amount, ameliorated
vu19Tg chemical treatment by environment: copper(2+) Long-pec central nervous system axon decreased length, abnormal
Long-pec central nervous system DsRed2 expression decreased amount, abnormal
vu19Tg chemical treatment by environment: copper(2+), chemical treatment by environment: 6-bromoindirubin-3'-oxime Long-pec central nervous system axon decreased length, ameliorated
Long-pec central nervous system DsRed2 expression amount, ameliorated
Full text @ BBA Gene Regulatory Mechanisms