ZFIN Figure: Zhang et al., 2020, Fig. 1

ZFIN ID: ZDB-FIG-220502-26

ZFIN ID: ZDB-FIG-220502-26

Zhang et al., 2020 - Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms 1863(10):194612 Full text @ BBA Gene Regulatory Mechanisms

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	DsRed2 EGFP mbpa mpz olig2 plp1a
Fish:	WT ck1Tg vu19Tg
Condition:	chemical treatment by environment: copper(2+)
Anatomical Terms:	spinal cord whole organism
Stage Range:	Long-pec to Day 4

PHENOTYPE:

Fish:	WT ck1Tg vu19Tg
Condition:	chemical treatment by environment: copper(2+)
Observed In:	central nervous system axon central nervous system myelin sheath spinal cord whole organism
Stage Range:	Long-pec to Day 5

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
DsRed2	vu19Tg	standard conditions	Long-pec	spinal cord	RTPCR
	vu19Tg	chemical treatment by environment: copper(2+)	Long-pec	spinal cord	RTPCR
EGFP	ck1Tg	standard conditions	Day 4	spinal cord	RTPCR
	ck1Tg	chemical treatment by environment: copper(2+)	Day 4	spinal cord	RTPCR
mbpa	WT	standard conditions	Day 4	spinal cord	ISH
			Day 4	whole organism	RTPCR
	WT	chemical treatment by environment: copper(2+)	Day 4	spinal cord	ISH
			Day 4	whole organism	RTPCR
mpz	WT	standard conditions	Day 4	whole organism	RTPCR
	WT	chemical treatment by environment: copper(2+)	Day 4	whole organism	RTPCR
olig2	WT	standard conditions	Day 4	spinal cord	ISH
	WT	chemical treatment by environment: copper(2+)	Day 4	spinal cord	ISH
plp1a	WT	standard conditions	Day 4	spinal cord	ISH
			Day 4	whole organism	RTPCR
	WT	chemical treatment by environment: copper(2+)	Day 4	spinal cord	ISH
			Day 4	whole organism	RTPCR

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
WT	chemical treatment by environment: copper(2+)	Day 4	spinal cord mbpa expression decreased amount, abnormal
		Day 4	spinal cord olig2 expression decreased amount, abnormal
		Day 4	spinal cord plp1a expression decreased amount, abnormal
		Day 4	whole organism mbpa expression decreased amount, abnormal
		Day 4	whole organism mpz expression decreased amount, abnormal
		Day 4	whole organism plp1a expression decreased amount, abnormal
		Day 5	central nervous system myelin sheath decreased thickness, abnormal
		Day 5	central nervous system myelin sheath loose, abnormal
ck1Tg	chemical treatment by environment: copper(2+)	Day 4	spinal cord EGFP expression decreased amount, abnormal
vu19Tg	chemical treatment by environment: copper(2+)	Long-pec	central nervous system axon decreased length, abnormal
		Long-pec	spinal cord DsRed2 expression decreased amount, abnormal

Full text @ BBA Gene Regulatory Mechanisms