ZFIN ID: ZDB-FIG-220502-26
Zhang et al., 2020 - Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms   1863(10):194612 Full text @ BBA Gene Regulatory Mechanisms
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Condition:
Anatomical Terms:
Stage Range: Long-pec to Day 4
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage Range: Long-pec to Day 5

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed2 vu19Tg standard conditions Long-pec spinal cord RTPCR
vu19Tg chemical treatment by environment: copper(2+) Long-pec spinal cord RTPCR
EGFP ck1Tg standard conditions Day 4 spinal cord RTPCR
ck1Tg chemical treatment by environment: copper(2+) Day 4 spinal cord RTPCR
mbpa WT standard conditions Day 4 spinal cord ISH
Day 4 whole organism RTPCR
WT chemical treatment by environment: copper(2+) Day 4 spinal cord ISH
Day 4 whole organism RTPCR
mpz WT standard conditions Day 4 whole organism RTPCR
WT chemical treatment by environment: copper(2+) Day 4 whole organism RTPCR
olig2 WT standard conditions Day 4 spinal cord ISH
WT chemical treatment by environment: copper(2+) Day 4 spinal cord ISH
plp1a WT standard conditions Day 4 spinal cord ISH
Day 4 whole organism RTPCR
WT chemical treatment by environment: copper(2+) Day 4 spinal cord ISH
Day 4 whole organism RTPCR
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: copper(2+) Day 4 spinal cord mbpa expression decreased amount, abnormal
Day 4 spinal cord olig2 expression decreased amount, abnormal
Day 4 spinal cord plp1a expression decreased amount, abnormal
Day 4 whole organism mbpa expression decreased amount, abnormal
Day 4 whole organism mpz expression decreased amount, abnormal
Day 4 whole organism plp1a expression decreased amount, abnormal
Day 5 central nervous system myelin sheath decreased thickness, abnormal
Day 5 central nervous system myelin sheath loose, abnormal
ck1Tg chemical treatment by environment: copper(2+) Day 4 spinal cord EGFP expression decreased amount, abnormal
vu19Tg chemical treatment by environment: copper(2+) Long-pec central nervous system axon decreased length, abnormal
Long-pec spinal cord DsRed2 expression decreased amount, abnormal
Full text @ BBA Gene Regulatory Mechanisms