Figure 8.

Summary of species-specific modes of retinal pigment epithelium (RPE) differentiation and its contribution to optic vesicle (OV) folding.

(A) The drawing on the top represent the dynamic of OV folding into an optic cup (OC). Green double arrow indicated RPE flattening, blue arrow rim involution whereas pink arrows indicate retinal basal constriction. Bottom row summarizes the alterations in OV folding observed after localized interference with RPE and neural retina (NR) cytoskeleton. (B) Schematic representation of the differential mechanisms by which the RPE in zebrafish (upper row) and in amniotes (lower row) expands its surface during OV folding morphogenesis. In zebrafish, the RPE enlarges its surface by cell stretching; in amniotes, including in humans, the RPE instead expands by cell proliferation with a less pronounced need of cell flattening.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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