FIGURE

Figure 5

ID

ZDB-FIG-211029-109

Publication

Crouzier et al., 2021 - Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish

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Figure 5

(A) Effect of the Tunicamycin (2 µg/mL, 24 h) challenge on ER stress gene expression levels in s1r^+25/+25 zebrafish larvae at 5 dpf. The selected genes were analyzed using cDNA prepared from whole zebrafish larvae and relative mRNA expression were expressed as percentage of s1r^WT + 0.1% DMSO controls. The fold change from 0.1% DMSO treatment is indicated. Data are expressed in mean ± SEM of n = 5 determination in each group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. DMSO treatment; ° p < 0.05, °° p < 0.01, °°° p < 0.001 vs. s1r^WT line; two-way ANOVA followed by unpaired t-test. (B) Schematic summary of ER stress pathway alterations observed in basal condition or after tunicamycin treatment in s1r^+25/+25 zebrafish line.

Expression Data

Genes:	atf4a atf4b atf6 ddit3 eif2s1a ern2 hsp90b1 hspa5 sigmar1 xbp1 (all 10)
Fish:	WT sigmar1^f19/f19
Condition:	chemical treatment by environment: tunicamycin
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT sigmar1^f19/f19
Condition:	chemical treatment by environment: tunicamycin
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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