Gene

ddit3

ID
ZDB-GENE-070410-90
Name
DNA-damage-inducible transcript 3
Symbol
ddit3 Nomenclature History
Previous Names
  • CHOP (1)
  • zgc:162630
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Is predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in ER overload response; positive regulation of intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of lipid biosynthetic process; and response to hypoxia. Predicted to be located in nucleus. Predicted to be part of CHOP-ATF3 complex; CHOP-ATF4 complex; and CHOP-C/EBP complex. Is expressed in brain; caudal fin; digestive system; and head. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
41 figures from 35 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Her et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddit3 Human Ortholog
No data available
Associated With ddit3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004827 Basic-leucine zipper domain
Family IPR016670 DNA damage-inducible transcript 3
Domain Details Per Protein
Protein Length Basic-leucine zipper domain DNA damage-inducible transcript 3
UniProtKB:A3KNX2 205
UniProtKB:F1Q964 242
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations