FIGURE

FIGURE 1

ID

ZDB-FIG-210807-1

Publication

Li et al., 2021 - An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer's Disease

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FIGURE 1

ACT attenuated AlCl₃-induced AD in zebrafish larvae. (A) The workflow of ACT-AD targets interaction network modeling. The size and color of nodes represented the degree of targets. The width of edges was consistent with the combined score of targets. (B) Top 30 of KEGG enrichment. (C) Illustration of KEGG pathway enrichment analysis. (D) The representative swimming trails of zebrafish larvae in the light and dark phase. (E) The average speed and speed change in different groups (n = 10). (F) DRR (%) and RE (%) in the drug treatment groups (n = 10). (G) The evaluation of AChE and ChAT activities (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.005, versus the AlCl₃ group. DPZ as the positive control.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: aluminium trichloride chemical treatment by environment: acteoside
Observed In:	swimming behavior whole organism acetylcholinesterase activity whole organism choline O-acetyltransferase activity
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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