FIGURE

Fig. 2

ID

ZDB-FIG-200814-2

Publication

Tao et al., 2020 - LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

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Fig. 2

LIN28B promotes the metastasis of MYCN-induced neuroblastoma. (A) Summary of neuroblastoma metastases in EGFP;MYCN, LIN28B_WT;MYCN, and LIN28B_MU;MYCN transgenic lines at 6 mo of age, five fish per group. Colored boxes indicate that metastasis was observed in the indicated organ while white boxes indicate no apparent metastasis. The difference in metastases between EGFP;MYCN and either LIN28B_WT;MYCN or LIN28B_MU;MYCN fish (P = 0.0476) was compared using the two-tailed Fisher’s exact test. (B and C) Representative images of neuroblastoma metastases in the sagittal sections of LIN28B_WT;MYCN fish by H&E staining (B) and immunohistochemical staining of TH (C). The organs harboring metastatic tumor cells are marked in B and C and are correspondingly magnified in D–L″. (Scale bar, 1 mm.) (D–L″) Magnified views of the organs shown in B and C showing H&E staining as well as immunostaining of TH and LIN28B in LIN28B_WT;MYCN fish. Green arrowheads indicate metastatic cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zdf16Tg zdf16Tg; zdf39Tg zdf16Tg; zdf40Tg
Observed In:	bony shelf above orbit neoplasm gill neoplasm head kidney neoplasm heart neoplasm interrenal gland neoplasm intestine neoplasm liver neoplasm pancreas neoplasm spleen neoplasm testis neoplasm
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA