ZFIN ID: ZDB-FIG-200814-2
Tao et al., 2020 - LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors. Proceedings of the National Academy of Sciences of the United States of America   117(28):16516-16526 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 2 LIN28B promotes the metastasis of MYCN-induced neuroblastoma. (A) Summary of neuroblastoma metastases in EGFP;MYCN, LIN28B_WT;MYCN, and LIN28B_MU;MYCN transgenic lines at 6 mo of age, five fish per group. Colored boxes indicate that metastasis was observed in the indicated organ while white boxes indicate no apparent metastasis. The difference in metastases between EGFP;MYCN and either LIN28B_WT;MYCN or LIN28B_MU;MYCN fish (P = 0.0476) was compared using the two-tailed Fisher’s exact test. (B and C) Representative images of neuroblastoma metastases in the sagittal sections of LIN28B_WT;MYCN fish by H&E staining (B) and immunohistochemical staining of TH (C). The organs harboring metastatic tumor cells are marked in B and C and are correspondingly magnified in D–L″. (Scale bar, 1 mm.) (D–L″) Magnified views of the organs shown in B and C showing H&E staining as well as immunostaining of TH and LIN28B in LIN28B_WT;MYCN fish. Green arrowheads indicate metastatic cells.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
zdf16Tg standard conditions Adult bony shelf above orbit neoplasm present, abnormal
Adult head kidney neoplasm present, abnormal
Adult interrenal gland neoplasm present, abnormal
zdf16Tg; zdf39Tg standard conditions Adult bony shelf above orbit neoplasm present, abnormal
Adult gill neoplasm present, abnormal
Adult head kidney neoplasm present, abnormal
Adult heart neoplasm present, abnormal
Adult interrenal gland neoplasm present, abnormal
Adult intestine neoplasm present, abnormal
Adult liver neoplasm present, abnormal
Adult pancreas neoplasm present, abnormal
Adult spleen neoplasm present, abnormal
zdf16Tg; zdf40Tg standard conditions Adult bony shelf above orbit neoplasm present, abnormal
Adult gill neoplasm present, abnormal
Adult head kidney neoplasm present, abnormal
Adult heart neoplasm present, abnormal
Adult interrenal gland neoplasm present, abnormal
Adult liver neoplasm present, abnormal
Adult pancreas neoplasm present, abnormal
Adult spleen neoplasm present, abnormal
Adult testis neoplasm present, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA