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Figure 12

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ZDB-FIG-200716-65

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Keller et al., 2020 - Validating the Paradigm That Biomechanical Forces Regulate Embryonic Cardiovascular Morphogenesis and Are Fundamental in the Etiology of Congenital Heart Disease

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Figure 12

Computational hemodynamic optimization predicts embryonic chick aortic arch selection. (A) Three-dimensional polymeric cast of a stage 18 aortic sac and arches with color representing wall shear stress magnitudes (1.) and parameterized stage 18 right lateral aortic arch geometry (2.). (B) Representative fluorescent dye injections and angle measurements in stage 21 (1.) and stage 24 (2.) chick embryos. Scale bar = 1 mm. (C) Power + diffusion optimization predicts the selection of the aortic arch IV though arches II and III remain patent for an outflow tract angle of 102 ° and an energy/diffusion ratio of 1.85. This was adapted with permission [162].

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cardiovasc Dev Dis