FIGURE

Figure 5

ID

ZDB-FIG-200129-8

Publication

Cen et al., 2019 - Exosomal Thrombospondin-1 Disrupts the Integrity of Endothelial Intercellular Junctions to Facilitate Breast Cancer Cell Metastasis

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Figure 5

Exosomal TSP1 derived from breast cancer cells suppresses the expression of HUVEC intracellular junction proteins. (A) mRNA transcription level of occludin, ZO-1, VE-cadherin, in HUVECs treated with different amount of LSKL. (B) mRNA transcription level of occludin, ZO-1, VE-cadherin, in HUVECs treated with MDA-MB-231-derived exosomes and different concentrations of LSKL. (C) mRNA transcription level of ZO-1 and VE-cadherin in HUVECs treated with exosomes derived from breast cancer cells differentially expressing TSP1. Data are shown as mean ± SD and representative of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001; ns, no significance by unpaired Student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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