FIGURE

Figure 3

ID

ZDB-FIG-200129-23

Publication

Cen et al., 2019 - Exosomal Thrombospondin-1 Disrupts the Integrity of Endothelial Intercellular Junctions to Facilitate Breast Cancer Cell Metastasis

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Figure 3

Exosomes derived from MDA-MB-231 cells regulate the expression of intercellular junction molecules in HUVECs. (A,B) Confocal microscopy images of vascular endothelial cadherin (VE-cadherin) (red) (A) and zona occluden-1 (ZO-1) (red) (B) in exosome-treated HUVECs stained with corresponding antibodies. Exosomes were labeled with Dio (green). Scale bar, 20 μm. (C) Mean fluorescence intensity for VE-cadherin and ZO-1 expression in exosome-treated and control HUVECs. (D) mRNA expression of intercellular junction molecules in exosome-treated and control HUVECs by qRT-PCR analysis. Data are shown as mean ± SD and representative of three independent experiments. ** p < 0.01, *** p < 0.001 by unpaired Student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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