FIGURE

Fig. 3

ID

ZDB-FIG-191028-11

Publication

Schlomann et al., 2019 - Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion

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Fig. 3

Low-dose ciprofloxacin collapses Enterobacter populations and suppresses small clusters in vivo. (A) Normalized abundances (number of CFUs scaled by untreated medians) of water and gut populations. N values left to right: 4, 20, 4, 20, 4, 19, 4, 20. Water N values denote number of flasks; gut N values denote number of fish. (B) Histograms of gut CFUs with pooled data from 24- to 48-h treatments. Counts indicate the number of individual fish with a given ${l o g}_{10}$ Enterobacter CFUs. Dashed lines indicate the mean of each set, showing an ∼1,000-fold reduction in intestinal Enterobacter abundance in antibiotic-treated fish. (C) Total number of bacterial clusters in the intestine, quantified from 3D images (Materials and Methods). (D) Maximum-intensity projections of 3D images of untreated (Top) and ciprofloxacin-treated (Bottom) Enterobacter populations. Insets show viability staining of bacteria expelled from the gut, with green and magenta indicating living and dead cells, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA