ZFIN ID: ZDB-FIG-190819-8
Su et al., 2019 - A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. Cancers   11(7) Full text @ Cancers
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibody:
Fish:
Anatomical Term:
Stage: Adult
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 10

Immunoreactive score of p-Akt immunostaining reveals that Akt is much more significantly activated in AURKA(V352I) than in AURKA(WT). (A) Representative images of p-AKT staining for PTEN in control, AURKA(WT), and AURKA(V352I) at 3, 5, 7, 9, and 11 months; (B) Selected enlarged images show the p-AKT signals from AURKA(WT)—11 M and AURKA(V352I)—11 M; (C) Statistical analysis of p-AKT immunostaining IRS score at 3, 5, 7, 9, and 11 months. The gray, orange, and blue colors represent control, AURKA(WT), and AURKA(V352I), respectively. Statistical analysis of results was performed using a two-tailed Student’s t-test. The error bar means standard deviation. Asterisks (*) represent the level of significance. * p-value ≤ 0.05; ** p-value ≤ 0.01; *** p-value ≤ 0.001.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab2-akt IHC nn1000Tg standard conditions Adult liver
IHC nn1010Tg standard conditions Adult liver
IHC nn1011Tg standard conditions Adult liver
Phenotype Details
Fish Conditions Stage Phenotype
nn1010Tg standard conditions Adult liver ab2-akt labeling increased amount, abnormal
nn1011Tg standard conditions Adult liver ab2-akt labeling increased amount, abnormal
Acknowledgments:
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