ZFIN ID: ZDB-FIG-190819-4
Su et al., 2019 - A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. Cancers   11(7) Full text @ Cancers
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 6

Hematoxylin and Eosin staining reveals that AURKA(V352I) dramatically promotes hepatocellular carcinoma (HCC) at 7 months, and AURKA(WT) promotes HCC at 9 months of age. (A) Representative images of HE staining in control, AURKA(WT) and AURKA(V352I) at 3, 5, 7, 9, and 11 months; (B,C) Statistical analysis of the AURKA(WT) and AURKA(V352I) HE stain results shown as percentage of fish displayed normal (gray), steatosis (green), hyperplasia (yellow), dysplasia (orange), and HCC (red) at different stages.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
nn1010Tg standard conditions Adult liver dysplastic, abnormal
Adult liver fatty, abnormal
Adult liver hyperplastic, abnormal
Adult liver hepatocellular carcinoma present, abnormal
nn1011Tg standard conditions Adult liver dysplastic, abnormal
Adult liver fatty, abnormal
Adult liver hyperplastic, abnormal
Adult liver hepatocellular carcinoma present, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Cancers for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Cancers