ZFIN ID: ZDB-FIG-190819-5
Su et al., 2019 - A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. Cancers   11(7) Full text @ Cancers
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 7

The immunoreactive score (IRS) of immunohistochemistry for the proliferating cell nuclear antigen (PCNA) was greater in AURKA(V352I) and AURKA(WT) than in control fish at 5 and 7 months. (A) Representative images of immunohistochemistry (IHC) staining for PCNA in control, AURKA(WT), and AURKA(V352I) at 3, 5, 7, 9, and 11 months; (B) Selected enlarged images show the nuclear signals of PCNA from AURKA(WT)—7 M and AURKA(V352I)—5 M; (C) Statistical analysis of PCNA immunostaining IRS score at 3, 5, 7, 9, and 11 months. IRS score of control fish (Tg(fabp10a:EGFP-mCherry) abbreviated as mC, AURKA(WT) and AURKA(V352I) is shown in red (3 M), orange (5 M), green (7 M), purple (9 M), and blue (11 M). Statistical analysis of results was performed using a two-tailed Student’s t-test. The error bar means standard deviation. Asterisks (*) represent the level of significance. * p-value ≤ 0.05; ** p-value ≤ 0.01; *** p-value ≤ 0.001.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
nn1010Tg standard conditions Adult liver cell population proliferation increased process quality, abnormal
nn1011Tg standard conditions Adult liver cell population proliferation increased process quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Cancers for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Cancers